|
KMID : 1004520100260010069
|
|
Journal of Dental Rehabilitation and Applied Science
2010 Volume.26 No. 1 p.69 ~ p.75
|
|
|
Muscle Weakness after Repeated Injection of Botulinum Toxin Type A Evaluated by Dental Prescale.
|
|
Byun Young-Sub
Song Ji-Hee
Choi Young-Chan
Kim Seong-Taek
|
|
|
Abstract
|
|
|
Botulinum toxin type A(BTX-A) has been applied successfully to treat masseteric hypertrophy. However it can cause
muscle weakness. This study was designed to measure the change in maximum bite force(MBF) after BTX-A injection
into human masseter muscle and to evaluate the influence of a booster(repeated) injection. Thirty volunteers completed
18-week follow-up and MBF was measured. At 18 weeks after the first injection, a booster injection was given to 14
patients and they were followed up until 18 weeks from the booster injection. The mean MBF was approximately 20%
lower at 2 weeks than before the injection, and it recovered gradually after 4 weeks to return to the preinjection level at
12 weeks. The MBF differed significantly between before the injection and at 2, 4, and 8 weeks after the injection(p<0.05).
In booster injection group(n=14),the MBF decreased markedly at 6 weeks(p<0.05),and it recovered gradually in 12 weeks.
The MBF was significantly reduced after booster injection of BTX-A into the human masseter muscle. The degree of
discomfort experienced by the subjects had little effect on normal mastication.
|
|
|
KEYWORD
|
|
|
muscle weakness, botulinum toxin type A, masseter muscle, booster injection
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|